Chemical Structure : Kamuvudine-9
CAS No.:
1995864-94-2
Kamuvudine-9
(K-9, Kamuvudine 9)
Catalog No.: PC-28304Not For Human Use, Lab Use Only.
Kamuvudine-9 (K-9) is a derivative of nucleoside reverse transcriptase inhibitor (NRTI) that inhibits inflammasome activation, disrupts interactions between NLRP3 and NIMA-related kinase 7 (NEK7) and between NLRP3 and NLR CARD domain containing 4 (NLRC4).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Kamuvudine-9 (K-9) is a derivative of nucleoside reverse transcriptase inhibitor (NRTI) that inhibits inflammasome activation, disrupts interactions between NLRP3 and NIMA-related kinase 7 (NEK7) and between NLRP3 and NLR CARD domain containing 4 (NLRC4).
Kamuvudine-9 (K-9) prevents neurological deficits and reverses preexisting paralysis and vision loss.
Kamuvudine-9 (K-9) promotes myelin and axonal preservation in the mouse spinal cord and abolished the increase in serum neurofilament light (NfL) chain.
Kamuvudine-9 (K-9) inhibits retinal inflammasome activation and photoreceptor death.
Kamuvudine-9 (K-9) protects retinal electrical function during the time of RRD and induces an improvement following retinal reattachmen in RRD/SRR model.
Physicochemical Properties
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M.Wt
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271.34
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Formula
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C11H17N3O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(dimethylamino)-1-((2S,5R)-2-(methoxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
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References
1. Magagnoli J, et al. medRxiv [Preprint]. 2023 Mar 20:2023.03.17.23287375.
2. Fowler BJ, Science. 2014; 346(6212): 1000–1003.
3. Huang P, et al. Invest Ophthalmol Vis Sci. 2023 May 1;64(5):3.
4. Yerramothu P, et al. Sci Transl Med. 2026 Sep 23;18(868):eaei2870.
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