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Keap1-Nrf2 inhibitor 25

Chemical Structure : Keap1-Nrf2 inhibitor 25

CAS No.:

Keap1-Nrf2 inhibitor 25

Catalog No.: PC-20558Not For Human Use, Lab Use Only.

Keap1-Nrf2 inhibitor 25 is a potent, orally bioavailable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with IC50 of 89 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Keap1-Nrf2 inhibitor 25 is a potent, orally bioavailable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with IC50 of 89 nM.
Keap1-Nrf2 inhibitor 25 (3-30 mg/kg p.o.) demonstrated dose-dependent manner for up-regulation of the antioxidant protein heme oxigenase-1 (HO-1) in rat kidneys.

Physicochemical Properties

M.Wt 383.46
Formula C23H26FNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(O)[C@H](C)[C@H](NC([C@@H](F)C1=CC=C2CCCCC2=C1)=O)C3=CC=C(C)C=C3

References

1. Kazuki Otake, et al. ACS Medicinal Chemistry Letter. April 7, 2023

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