Chemical Structure : Keap1-Nrf2 inhibitor 28
CAS No.:
3039835-63-4
Keap1-Nrf2 inhibitor 28
Catalog No.: PC-25376Not For Human Use, Lab Use Only.
Keap1-Nrf2 inhibitor 28 is a high potent small molecule inhibitor of Keap1-Nrf2 with Ki of 8.8 nM, induces expression of NQO1 mRNA with EC50 of 60.1 nM in BEAS-2B cells with qPCR-based assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Keap1-Nrf2 inhibitor 28 is a high potent small molecule inhibitor of Keap1-Nrf2 with Ki of 8.8 nM, induces expression of NQO1 mRNA with EC50 of 60.1 nM in BEAS-2B cells with qPCR-based assays.
Keap1-Nrf2 inhibitor 28 markedly reduces the expression of NLRP3, a key pattern-recognition receptor (PRR) domain of the inflammasome in macrophage-derived THP-1 cells, prevents the cleavage of gasdermin D (GSDMD), a process otherwise mediated by active caspase-1.
Keap1-Nrf2 inhibitor 28 shows anti-inflammatory effects by downregulating NLRP3 inflammasome and STING signalling.
Keap1-Nrf2 inhibitor 28 activates specific Nrf2-controlled genes and key immune signalling pathways.
Physicochemical Properties
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M.Wt
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517.62
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Formula
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C31H35NO6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(7-(2-(cycloheptylamino)-2-oxoethoxy)naphthalen-2-yl)-3-(7-methyl-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propanoic acid
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References
1. Lin C, et al. Angew Chem Int Ed Engl. 2025 Aug 21:e202508121.
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