Chemical Structure : Keap1-p-p62 inhibitor 13
CAS No.:
Keap1-p-p62 inhibitor 13
(Keap1-p-p62-IN-1)
Catalog No.: PC-27016Not For Human Use, Lab Use Only.
Keap1-p-p62 inhibitor 13 (Keap1-p-p62-IN-1) is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.11 uM, high selectivity over inhibition of Keap1-Nrf2 interaction.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Keap1-p-p62 inhibitor 13 (Keap1-p-p62-IN-1) is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.11 uM, high selectivity over inhibition of Keap1-Nrf2 interaction.
Keap1-p-p62 inhibitor 13 specifically inhibitsNrf2 activity in p62 aberrant hepatocellular carcinoma (HCC) cells by selectively disrupting Keap1-p-p62 interaction and normalizing Nrf2 ubiquitination.
Keap1-p-p62 inhibitor 13 sensitizes p62 aberrant HCC to ferroptosis induced by sorafenib (TGI = 95.3%).
Physicochemical Properties
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M.Wt
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613.73
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Formula
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C33H35N5O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((4-((N-((1H-tetrazol-5-yl)methyl)-2,4,6-trimethylphenyl)sulfonamido)naphthalen-1-yl)oxy)-2-(4-(tert-butyl)phenyl)acetic acid
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References
1. Ziquan Zhao, et al. J Med Chem. 2026 Jun 11;69(11):13141-13164.
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