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Kinetin riboside

Chemical Structure : Kinetin riboside

CAS No.: 4338-47-0

Kinetin riboside (N6-Furfuryladenosine;FAdo)

Catalog No.: PC-42305Not For Human Use, Lab Use Only.

A cytokinin analog that displays potent antiproliferative activity against various human cancer cell lines.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A cytokinin analog that displays potent antiproliferative activity against various human cancer cell lines; inhibits MiPaCa-2 cell proliferation with IC50 of 0.27 uM; induceds marked suppression of CCND2 transcription and rapidly suppresses cyclin D1 and D2 protein expression in primary myeloma cells and tumor lines, causing cell cycle arrest, tumor cell-selective apoptosis, and inhibition of myeloma growth in xenografted mice; also can activate PINK1 in cells independent of mitochondrial depolarization.

Physicochemical Properties

M.Wt 347.32598
Formula C15H17N5O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 29 mg/mL

Chemical Name/SMILES

Adenosine, N-(2-furanylmethyl)-

References

1. Osgerby L, et al. J Med Chem. 2017 Apr 27;60(8):3518-3524.

2. Tiedemann RE, et al. J Clin Invest. 2008 May;118(5):1750-64.

3. Hertz NT, et al. Cell. 2013 Aug 15;154(4):737-47.

4. Choi BH, et al. J Biol Chem. 2010 Mar 26;285(13):9770-9.

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