KuWal151 |CAS: 2341841-06-1 Probechem Biochemicals

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Chemical Structure : KuWal151

KuWal151 (KuWal 151)

Catalog No.: PC-63470Not For Human Use, Lab Use Only.

KuWal151 is a potent, selective cdc2-like kinase (CLK) inhibitor with IC50 of 88/510/28 nM for CLK1/2/4, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KuWal151 is a potent, selective cdc2-like kinase (CLK) inhibitor with IC50 of 88/510/28 nM for CLK1/2/4, respectively.
KuWal151 shows no activity against CLK3 (IC50>10 uM), exhibits selectivity versus DYRK1A and other DYRK kinases.
KuWal151 displays a potent antiproliferative activity in an array of cultured cancer cell lines (HCT-116 cell GI50=191 nM).

Physicochemical Properties

M.Wt	282.727
Formula	C16H11ClN2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-chlorophenyl)-6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one

References

1. Walter A, et al. PLoS One. 2018 May 3;13(5):e0196761.

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KuWal151 (KuWal 151)

Biological Activity

Physicochemical Properties

References

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