Catalog No.: PC-26771Not For Human Use, Lab Use Only.
Kukoamine A (KuA) is a potent and selective inhibitor of Crithidia fasciculata trypanothione reductase (TR) with Ki of 1.8 uM, with no significant inhibition on human glutathione reductase, possesses antioxidant, anti-inflammatory activities.
Kukoamine A (KuA) is a potent and selective inhibitor of Crithidia fasciculata trypanothione reductase (TR) with Ki of 1.8 uM, with no significant inhibition on human glutathione reductase, possesses antioxidant, anti-inflammatory activities. Kukoamine A inhibits human glioblastoma cell growth and migration in vitro and in vivo through apoptosis induction and epithelial-mesenchymal transition attenuation by downregulating expressions of 5-LOX and C/EBPβ. Kukoamine A disrupts AARS2-AP-2γ interaction and, demonstrates improved liver targeting, potent antitumour activity and synergy with PD-1 blockade in hepatocellular carcinoma (HCC).
