Catalog No.: PC-25519Not For Human Use, Lab Use Only.
Kuwanon C (KWN-C, Mulberrin) is an effective inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with IC50 of 1.8 uM, also inhibits SIRT1 activity via targeting activity of the TGF-β1-Smad2/3-JNK1 signaling pathway.
Kuwanon C (KWN-C, Mulberrin) is an effective inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with IC50 of 1.8 uM, also inhibits SIRT1 activity via targeting activity of the TGF-β1-Smad2/3-JNK1 signaling pathway. KWN-C suppressed pSmad2/3–JNK1 levels, which subsequently abrogated the phosphorylation of SIRT1S27 and SIRT1S47. KWN-C decreases KRASMut activity via reducing SIRT1 activity and enhancing the acetylation of KRASMut. KWN-C synergistically decreased KRASMut lung cancer proliferation combined with Cisplatin and Pemetrexed. KWN-C synergistically reduces tumor burden in lung orthotropic models bearing KRAS G12C combined with Cisplatin and Pemetrexed.
1. Wen F, et al. Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharm Biol. 2016;54(2):293-302.
