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L-162313

Chemical Structure : L-162313

CAS No.: 151488-11-8

L-162313 (L-162,313)

Catalog No.: PC-27613Not For Human Use, Lab Use Only.

L-162313 (L-162,313) is a potent, selective non-peptide agonist of angiotensin II AT1 and AT2 receptors with IC50 of 1.1 and 2.0 nM, stimulates phosphoinositide hydrolysis in COS-7 cells transfected with the rat AT1 receptor with EC50 of 33 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

L-162313 (L-162,313) is a potent, selective non-peptide agonist of angiotensin II AT1 and AT2 receptors with IC50 of 1.1 and 2.0 nM, stimulates phosphoinositide hydrolysis in COS-7 cells transfected with the rat AT1 receptor with EC50 of 33 nM.

Physicochemical Properties

M.Wt 582.78
Formula C30H38N4O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Butyl ((3-(4-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)-5-isobutylthiophen-2-yl)sulfonyl)carbamate

References

1. Kivlighn SD, et al. Am J Physiol. 1995 Mar;268(3 Pt 2):R820-3.

2. Wan Y, et al. J Med Chem. 2004 Mar 11;47(6):1536-46.

3. Kivlighn SD, et al. Am J Physiol. 1995 Mar;268(3 Pt 2):R820-3.

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