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L-165041

Chemical Structure : L-165041

CAS No.: 79558-09-1

L-165041 (L 165041;L165041)

Catalog No.: PC-45781Not For Human Use, Lab Use Only.

L-165041 (L165041) is a selective PPARδ agonist with Ki of 6 nM, >120 fold selectivity over PPARγ.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

L-165041 (L165041) is a selective PPARδ agonist with Ki of 6 nM, >120 fold selectivity over PPARγ.
L-165041 inhibits cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells.
L-165041 inhibits rat VSMC proliferation in a dose dependent manner by blocking G(1) to S phase progression and repressing the phosphorylation of Rb, also inhibits PDGF-induced expression of cyclin D1 and CDK4.
L-165041 significantly lowers plasma cholesterol without major changes in very low or low density lipoproteins in db/db mice.

Physicochemical Properties

M.Wt 402.4377
Formula C22H26O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Acetic acid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-

References

1. Leibowitz MD, et al. FEBS Lett. 2000 May 19;473(3):333-6.

2. Rival Y, et al. Eur J Pharmacol. 2002 Jan 25;435(2-3):143-51.

3. Lim HJ, et al. Atherosclerosis. 2009 Feb;202(2):446-54.

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