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Chemical Structure : L-165041
CAS No.: 79558-09-1
Catalog No.: PC-45781Not For Human Use, Lab Use Only.
A selective PPARδ agonist with Ki of 6 nM, >120 fold selectivity over PPARγ.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $76 | In stock | |
| 50 mg | $304 | In stock | |
| 100 mg | $504 | In stock |
Bulk size, bulk discount!
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A selective PPARδ agonist with Ki of 6 nM, >120 fold selectivity over PPARγ; inhibits cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells; inhibits rat VSMC proliferation in a dose dependent manner by blocking G(1) to S phase progression and repressing the phosphorylation of Rb, also inhibits PDGF-induced expression of cyclin D1 and CDK4; significantly lowers plasma cholesterol without major changes in very low or low density lipoproteins in db/db mice.
| M.Wt | 402.4377 | |
| Formula | C22H26O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetic acid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]- |
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1. Leibowitz MD, et al. FEBS Lett. 2000 May 19;473(3):333-6.
2. Rival Y, et al. Eur J Pharmacol. 2002 Jan 25;435(2-3):143-51.
3. Lim HJ, et al. Atherosclerosis. 2009 Feb;202(2):446-54.
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