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L-257

Chemical Structure : L-257

CAS No.: 877120-88-2

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L-257 (DDAH1 inhibitor L257)

Catalog No.: PC-36015Not For Human Use, Lab Use Only.

L-257 (DDAH-1 inhibitor L-257) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM, Ki of 13 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    L-257 (DDAH-1 inhibitor L-257) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM, Ki of 13 uM.
    L-257 shows no direct inhibitory activity against NO synthase or effects on endothelium-denuded vessels.
    L-257 impairs vascular homeostasis, improves survival, haemodynamics and organ function in experimental septic shock.

    Physicochemical Properties

    M.Wt 232.284
    Formula C9H20N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N5-[Imino[(2-methoxyethyl)amino]methyl]-L-ornithine

    References

    1. Nandi M, et al. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2589-97.

    2. Wang Z, et al. Biochem J. 2014 Jun 1;460(2):309-16.

    3. Rossiter S, et al. J Med Chem. 2005 Jul 14;48(14):4670-8.

    4. Leiper J, et al. Nat Med. 2007 Feb;13(2):198-203.

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