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L-291

Chemical Structure : L-291

CAS No.: 887127-90-4

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L-291 (DDAH1 inhibitor L291)

Catalog No.: PC-36016Not For Human Use, Lab Use Only.

L-291 (DDAH-1 inhibitor L-291) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    L-291 (DDAH1 inhibitor L291) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM.
    L-291 shows no direct inhibitory activity against NO synthase or effects on endothelium-denuded vessels; impairs vascular homeostasis, also reduces NO synthesis in cultured dorsal root ganglia neurons.
    L-291 reduces both neuronal and behavioral measures of formalin-induced central sensitization after spinal application.

    Physicochemical Properties

    M.Wt 244.339
    Formula C11H24N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-(6-amino-7-oxononyl)-3-methoxyguanidine

    References

    1. Leiper J, et al. Nat Med. 2007 Feb;13(2):198-203.

    2. DʼMello R, et al. Pain. 2015 Oct;156(10):2052-60.

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