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Chemical Structure : L-291
Catalog No.: PC-36016Not For Human Use, Lab Use Only.
L-291 (DDAH-1 inhibitor L-291) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM.
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L-291 (DDAH1 inhibitor L291) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM.
L-291 shows no direct inhibitory activity against NO synthase or effects on endothelium-denuded vessels; impairs vascular homeostasis, also reduces NO synthesis in cultured dorsal root ganglia neurons.
L-291 reduces both neuronal and behavioral measures of formalin-induced central sensitization after spinal application.
| M.Wt | 244.339 | |
| Formula | C11H24N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Leiper J, et al. Nat Med. 2007 Feb;13(2):198-203.
2. DʼMello R, et al. Pain. 2015 Oct;156(10):2052-60.
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