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L-338192

Chemical Structure : L-338192

CAS No.: 1421702-02-4

L-338192 (L338192)

Catalog No.: PC-61808Not For Human Use, Lab Use Only.

L-338192 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 29 uM in AlphaScreen assay.

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    Biological Activity

    L-338192 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 29 uM in AlphaScreen assay.
    L-338192 displays 4.8-fold and 3.8-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions, respectively.

    Physicochemical Properties

    M.Wt 353.407
    Formula C15H15NO5S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-3-(5-(2,3-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid

    References

    1. Zhang M, et al. ACS Med Chem Lett. 2013 Jan 8;4(2):306-11.

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