Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : L-745870
CAS No.: 158985-00-3
Catalog No.: PC-21106Not For Human Use, Lab Use Only.
L-745870 (L-745,870) is is a potent, selective, brain-penetrant and orally active dopamine D4 receptor (D4R) antagonist with Ki of 0.43 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
L-745870 (L-745,870) is is a potent, selective, brain-penetrant and orally active dopamine D4 receptor (D4R) antagonist with Ki of 0.43 nM.
L-745870 is >100-fold selective for D4R over other dopamine receptors (D1R, D2R, D3R, and D5R) with subnanomolar affinity.
L-745870 blocks the inhibition of forskolin-stimulated adenylate cyclase activity in transfected human embryonic kidney (HEK293) and Chinese hamster ovary (CHO) cells.
L-745870 blocks dopamine-induced inhibition of Ca2+ currents in transfected GH4C1 pituitary cells.
L745870 (10 mg/kg p.o.) induces mild sedation and extrapyramidal motor symptoms, notably bradykinesia.
| M.Wt | 326.83 | |
| Formula | C18H19ClN4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-[[4-(4-Chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine |
|
1. Patel S, et al. J Pharmacol Exp Ther. 1997 Nov;283(2):636-47.
2. Bristow LJ, et al. Trends Pharmacol Sci. 1997 Jun;18(6):186-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
