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Chemical Structure : L-745870
CAS No.: 158985-00-3
Catalog No.: PC-21106Not For Human Use, Lab Use Only.
L-745870 (L-745,870) is is a potent, selective, brain-penetrant and orally active dopamine D4 receptor (D4R) antagonist with Ki of 0.43 nM.
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L-745870 (L-745,870) is is a potent, selective, brain-penetrant and orally active dopamine D4 receptor (D4R) antagonist with Ki of 0.43 nM.
L-745870 is >100-fold selective for D4R over other dopamine receptors (D1R, D2R, D3R, and D5R) with subnanomolar affinity.
L-745870 blocks the inhibition of forskolin-stimulated adenylate cyclase activity in transfected human embryonic kidney (HEK293) and Chinese hamster ovary (CHO) cells.
L-745870 blocks dopamine-induced inhibition of Ca2+ currents in transfected GH4C1 pituitary cells.
L745870 (10 mg/kg p.o.) induces mild sedation and extrapyramidal motor symptoms, notably bradykinesia.
| M.Wt | 326.83 | |
| Formula | C18H19ClN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[[4-(4-Chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine |
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1. Patel S, et al. J Pharmacol Exp Ther. 1997 Nov;283(2):636-47.
2. Bristow LJ, et al. Trends Pharmacol Sci. 1997 Jun;18(6):186-8.
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