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L-870810

Chemical Structure : L-870810

CAS No.: 410544-95-5

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L-870810 (L 870810;L870810)

Catalog No.: PC-70242Not For Human Use, Lab Use Only.

A potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    L-870810 is a potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties.
    L-870810 exhibits broad-spectrum activity against WT and multidrug-resistant HIV-1, HIV-2, and SIV; orally bioavailable.

    Physicochemical Properties

    M.Wt 430.454
    Formula C20H19FN4O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(1,1-dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-8-hydroxy-1,6-naphthyridine-7-carboxamide

    References

    1. Hazuda DJ, et al. Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11233-8.

    2. Zeng LF, et al. J Med Chem. 2012 Nov 26;55(22):9492-509.

    3. Hombrouck A, et al. Antimicrob Agents Chemother. 2008 Jun;52(6):2069-78.

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