Catalog No.: PC-61157Not For Human Use, Lab Use Only.
L-Moses (PCAF BRD inhibitor L-45) is a potent, selective, and cell-active PCAF (KAT2B) bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4.
L-Moses (PCAF BRD inhibitor L-45) is a potent, selective, and cell-active PCAF (KAT2B)bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4.
L-Moses disrupts PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, shows high selectivity for PCAF and GCN5 bromodomain (Kd=600 nM).
L-Moses shows no observable cytotoxicity in PBMCs, good cell-permeability, and metabolic stability in human and mouse liver microsomes.
