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L-α-Hydroxyglutaric acid disodium

Chemical Structure : L-α-Hydroxyglutaric acid disodium

CAS No.: 63512-50-5

L-α-Hydroxyglutaric acid disodium (L-2-Hydroxyglutarate;L-2-HG)

Catalog No.: PC-62978Not For Human Use, Lab Use Only.

L-α-Hydroxyglutaric acid disodium (L-2-Hydroxyglutarate, L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.

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Biological Activity

L-α-Hydroxyglutaric acid disodium (L-2-Hydroxyglutarate, L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
L-α-Hydroxyglutaric acid disodium comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 0.628 mM.
L-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.

Physicochemical Properties

M.Wt 192.08
Formula C5H6Na2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Pentanedioic acid, 2-hydroxy-, disodium salt, (S)- (9CI)

References

1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30.

2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.

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