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Chemical Structure : L-α-Hydroxyglutaric acid disodium
CAS No.: 63512-50-5
Catalog No.: PC-62978Not For Human Use, Lab Use Only.
L-α-Hydroxyglutaric acid disodium (L-2-Hydroxyglutarate, L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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L-α-Hydroxyglutaric acid disodium (L-2-Hydroxyglutarate, L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
L-α-Hydroxyglutaric acid disodium comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 0.628 mM.
L-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
| M.Wt | 192.08 | |
| Formula | C5H6Na2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Pentanedioic acid, 2-hydroxy-, disodium salt, (S)- (9CI) |
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1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30.
2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
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