Catalog No.: PC-62978Not For Human Use, Lab Use Only.
L-α-Hydroxyglutaric acid disodium (L-2-Hydroxyglutarate, L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
L-α-Hydroxyglutaric acid disodium (L-2-Hydroxyglutarate, L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
L-α-Hydroxyglutaric acid disodium comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 0.628 mM.
L-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
