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L524-0366

Chemical Structure : L524-0366

CAS No.: 951612-19-4

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L524-0366 (L 524-0366)

Catalog No.: PC-20808Not For Human Use, Lab Use Only.

L524-0366 is a small-molecule inhibitor of Fn14, binds specifically to the Fn14 receptor and disrupts TWEAK-Fn14 interaction.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

L524-0366 is a small-molecule inhibitor of Fn14, binds specifically to the Fn14 receptor and disrupts TWEAK-Fn14 interaction.
L524-0366 suppresses TWEAK-induced cell migration and survival in glioblastoma cells.
L524-0366 is a small molecule inhibitor to the TWEAK-Fn14 signaling axis.

Physicochemical Properties

M.Wt 308.78
Formula C13H13ClN4OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(C1=CN(C2=CC=CC(Cl)=C2)N=N1)N3CCSCC3

References

1. Ryne Holmberg, et al. Mol Cancer Res. 2023 Feb 1;21(2):170-186.

2. Harshil D. Dhruv, et al. Cancer Res (2014) 74 (19_Supplement): 1780.

3. Short C, et al. Hepatology. 2023 May 1;77(5):1639-1653.

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