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Chemical Structure : L 741742 hydrochloride
Catalog No.: PC-60615Not For Human Use, Lab Use Only.
A potent and highly selective D4 dopamine receptor antagonist with Ki of 3.5 nM, >200-fold selectivity over D2 and D3 receptors.
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A potent and highly selective D4 dopamine receptor antagonist with Ki of 3.5 nM, >200-fold selectivity over D2 and D3 receptors; also selectively inhibits GBM neural stem cells (GNS) growth and promotes differentiation of normal neural stem cells.
| M.Wt | 417.38 | |
| Formula | C23H25N2ClO.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rowley M, et al. J Med Chem. 1996 May 10;39(10):1943-5.
2. Dolma S, et al. Cancer Cell. 2016 Jun 13;29(6):859-873.
3. Cao BJ, et al. Eur J Pharmacol. 1997 Sep 24;335(2-3):117-25.
4. Root DH, et al. J Neurosci. 2015 Feb 25;35(8):3460-9.
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