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L 741742 hydrochloride

Chemical Structure : L 741742 hydrochloride

CAS No.: 874882-93-6

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L 741742 hydrochloride (L-741742;L741,742;L741742)

Catalog No.: PC-60615Not For Human Use, Lab Use Only.

A potent and highly selective D4 dopamine receptor antagonist with Ki of 3.5 nM, >200-fold selectivity over D2 and D3 receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent and highly selective D4 dopamine receptor antagonist with Ki of 3.5 nM, >200-fold selectivity over D2 and D3 receptors; also selectively inhibits GBM neural stem cells (GNS) growth and promotes differentiation of normal neural stem cells.

Physicochemical Properties

M.Wt 417.38
Formula C23H25N2ClO.HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride

References

1. Rowley M, et al. J Med Chem. 1996 May 10;39(10):1943-5.

2. Dolma S, et al. Cancer Cell. 2016 Jun 13;29(6):859-873.

3. Cao BJ, et al. Eur J Pharmacol. 1997 Sep 24;335(2-3):117-25.

4. Root DH, et al. J Neurosci. 2015 Feb 25;35(8):3460-9.

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