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Chemical Structure : LBL1
Catalog No.: PC-63448Not For Human Use, Lab Use Only.
LBL1 (Lamin A inhibitor LBL1) is a novel pyrroloquinazoline compound with significant anticancer activity, targets nuclear lamins and binds to the coiled-coil domain of lamin A (Kd=5.11 uM).
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LBL1 (Lamin A inhibitor LBL1) is a novel pyrroloquinazoline compound with significant anticancer activity, targets nuclear lamins and binds to the coiled-coil domain of lamin A (Kd=5.11 uM).
LBL1 demonstrates growth inhibitory activities against MDA-MB-468 and MDA-MB-231 breast cancer cell lines with GI50 of 0.44 and 1.60 uM, respectively.
LBL1 binds to LA(1-387) both in vitro and in living cells.
| M.Wt | 353.385 | |
| Formula | C21H15N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen J, et al. Medchemcomm. 2013 Sep 1;4(9):1275-1282.
2. Li BX, et al. ACS Chem Biol. 2018 Apr 19. doi: 10.1021/acschembio.8b00266.
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