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LBL1

Chemical Structure : LBL1

CAS No.: 1605301-58-3

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LBL1 (Lamin A inhibitor LBL1)

Catalog No.: PC-63448Not For Human Use, Lab Use Only.

LBL1 (Lamin A inhibitor LBL1) is a novel pyrroloquinazoline compound with significant anticancer activity, targets nuclear lamins and binds to the coiled-coil domain of lamin A (Kd=5.11 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LBL1 (Lamin A inhibitor LBL1) is a novel pyrroloquinazoline compound with significant anticancer activity, targets nuclear lamins and binds to the coiled-coil domain of lamin A (Kd=5.11 uM).
    LBL1 demonstrates growth inhibitory activities against MDA-MB-468 and MDA-MB-231 breast cancer cell lines with GI50 of 0.44 and 1.60 uM, respectively.
    LBL1 binds to LA(1-387) both in vitro and in living cells.

    Physicochemical Properties

    M.Wt 353.385
    Formula C21H15N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1-amino-7H-pyrrolo[3,2-f]quinazolin-3-yl)-2-naphthamide

    References

    1. Chen J, et al. Medchemcomm. 2013 Sep 1;4(9):1275-1282.

    2. Li BX, et al. ACS Chem Biol. 2018 Apr 19. doi: 10.1021/acschembio.8b00266.

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