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LBM22

Chemical Structure : LBM22

CAS No.:

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LBM22

Catalog No.: PC-23183Not For Human Use, Lab Use Only.

LBM22 is a potent, small molecule inhibitor of CDC2-like kinase 2 (CLK2) with IC50 of 3.9 nM, exhibits broad suppression of NSCLC cells proliferation and induction of apoptosis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LBM22 is a potent, small molecule inhibitor of CDC2-like kinase 2 (CLK2) with IC50 of 3.9 nM, exhibits broad suppression of NSCLC cells proliferation and induction of apoptosis.
LBM22 dose-dependently suppressed SR protein phosphorylation (pSRSF4, pSRSF5, and pSRSF6) in NSCLC cells, while downregulating the expression of Wnt pathway-related proteins (p-β-catenin, Axin 2, and c-Myc) as well as anti-apoptotic proteins (Bcl-2 and Mcl-1).
LBM22 displayed significant antiproliferative activity in 3D cultured H1975OR cells.

Physicochemical Properties

M.Wt 512.52
Formula C28H22F2N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4,5-Di (furan-2-yl)-1H-imidazole-2-yl)-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole

References

1. Hu T, et al. Eur J Med Chem. 2024 Oct 9;280:116952.

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