Chemical Structure : LC-0296
CAS No.:
LC-0296
(LC0296)
Catalog No.: PC-21027Not For Human Use, Lab Use Only.
LC-0296 (LC0296) is a selective sirtuin-3 (SIRT3) inhibitor with IC50 of 3.6 uM, shows 20- and 10-fold selectivity over SIRT1 and SIRT2 respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LC-0296 (LC0296) is a selective sirtuin-3 (SIRT3) inhibitor with IC50 of 3.6 uM, shows 20- and 10-fold selectivity over SIRT1 and SIRT2 respectively.
LC-0296 (75 uM) inhibits HNSCC cell survival without affecting normal human oral keratinocytes.
LC-0296 inhibits cell growth and proliferation and promotes apoptosis of HNSCC cells.
LC-0296 enhances the sensitivity of HNSCC cells to both radiation and chemotherapeutic drugs.
LC-0296 inhibits de-acetylation by SIRT3 and increases mitochondrial protein acetylation in HNSCC cells.
LC-0296 inhibits cell survival and enhances apoptosis via modulating reactive oxygen species (ROS) levels in head and neck squamous cell carcinoma (HNSCC) cells.
Physicochemical Properties
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M.Wt
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542.59
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Formula
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C30H30N4O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(OC)[C@@H](NC(OCC1=CC=CC=C1)=O)CCC(NC2=CC=CC3=C2C=CN3CC4=CC=CC(C(N)=O)=C4)=O
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References
1. Alhazzazi TY, et al. Anticancer Res. 2016 Jan;36(1):49-60.
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