LC-04-045

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Chemical Structure : LC-04-045

Catalog No.: PC-27601Not For Human Use, Lab Use Only.

LC-04-045 is a potent, selective molecular degrader of NIMA-related kinase 7 (NEK7) with DC50 of 7 nM, Dmax of 90 % in MOLT-4 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LC-04-045 is a potent, selective molecular degrader of NIMA-related kinase 7 (NEK7) with DC50 of 7 nM, Dmax of 90 % in MOLT-4 cells.
LC-04-045 displays high selectivity for NEK7 across the proteome.
LC-04-045 effectively inhibits secretion of the downstream cytokines, including IL-1β and IL-18.

Physicochemical Properties

M.Wt	566.06
Formula	C32H28ClN5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(5-(7-((2'-chloro-[1,1'-biphenyl]-2-yl)methyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Lu Chen, et al. Angew Chem Int Ed Engl. 2025 Mar 17;64(12):e202500169.

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LC-04-045

Biological Activity

Physicochemical Properties

References

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