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Chemical Structure : LC-MI-3
Catalog No.: PC-22314Not For Human Use, Lab Use Only.
LC-MI-3 is a potent, selective and orally bioavailable PROTAC degrader of interleukin-1 receptor-associated kinase 4 (IRAK4) with DC50 of 47.3 nM in RAW264.7 cells, Dmax of 91%.
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LC-MI-3 is a potent, selective and orally bioavailable PROTAC degrader of interleukin-1 receptor-associated kinase 4 (IRAK4) with DC50 of 47.3 nM in RAW264.7 cells, Dmax of 91%.
LC-MI-3-induced CRBN recruitment promotes IRAK4 ubiquitination and degradation, via the ubiquitin/proteasome system.
LC-MI-3 does not degrader RIOK1 IKZF1, IKZF3, and SALL4.
LC-MI-3 treatment shows potency to normalize LPS-induced interleukin-6 (IL-6) and tumor necrosis factor α (TNFα) mRNA expression as well as cytokine production in macrophages.
LC-MI-3 (20 mg/kg) suppresses lung injury in the LPS-induced mouse ALI model, attenuates Escherichia coli-induced inflammatory reaction and sepsis, suppresses the TLR7-mediated inflammatory reaction in the TLR7-driven psoriasis model.
| M.Wt | 744.77 | |
| Formula | C39H36N8O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lingfeng Chen, et al. J Med Chem. 2024 May 9. doi: 10.1021/acs.jmedchem.4c00181.
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