Chemical Structure : LC3in-C42
CAS No.:
LC3in-C42
Catalog No.: PC-22679Not For Human Use, Lab Use Only.
LC3in-C42 is a potent, covalent and cell-active LC3A/B inhibitor with IC50 of 7.6 nM in AlphaScreen assay, binds to LC3B selectively based on K49, potently inhibits autophagy.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LC3in-C42 is a potent, covalent and cell-active LC3A/B inhibitor with IC50 of 7.6 nM in AlphaScreen assay, binds to LC3B selectively based on K49, potently inhibits autophagy.
LC3in-C42 does not show any impact on γ-aminobutyric acid receptor-associated proteins (GABARAPs).
LC3in-C42 (5 uM) can completely disrupt the interaction between LC3A/B and P62, but not other four LC3 family proteins.
LC3in-C42 (10 uM) attenuates LC3-I/II lipidation in a dose-dependent manner in HeLa cells when the autophagy is induced, significantly inhibits P62 degradation.
LC3in-C42 (2.5 uM) almost completely impairs autophagosome and autophagolysosome formation in HeLa cells.
Physicochemical Properties
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M.Wt
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394.30
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Formula
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C19H21Cl2N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(5,6-Dichloro-1H-indol-4-yl)-2-(((2-(dimethylamino)ethyl)amino)methylene)cyclohexane-1,3-dione
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References
1. Zhenfei Zhou, et al. J Med Chem. 2024 Jul 15. doi: 10.1021/acs.jmedchem.4c00898
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