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Chemical Structure : LC3in-C42
Catalog No.: PC-22679Not For Human Use, Lab Use Only.
LC3in-C42 is a potent, covalent and cell-active LC3A/B inhibitor with IC50 of 7.6 nM in AlphaScreen assay, binds to LC3B selectively based on K49, potently inhibits autophagy.
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LC3in-C42 is a potent, covalent and cell-active LC3A/B inhibitor with IC50 of 7.6 nM in AlphaScreen assay, binds to LC3B selectively based on K49, potently inhibits autophagy.
LC3in-C42 does not show any impact on γ-aminobutyric acid receptor-associated proteins (GABARAPs).
LC3in-C42 (5 uM) can completely disrupt the interaction between LC3A/B and P62, but not other four LC3 family proteins.
LC3in-C42 (10 uM) attenuates LC3-I/II lipidation in a dose-dependent manner in HeLa cells when the autophagy is induced, significantly inhibits P62 degradation.
LC3in-C42 (2.5 uM) almost completely impairs autophagosome and autophagolysosome formation in HeLa cells.
| M.Wt | 394.30 | |
| Formula | C19H21Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhenfei Zhou, et al. J Med Chem. 2024 Jul 15. doi: 10.1021/acs.jmedchem.4c00898
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