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LCS-1.34

Chemical Structure : LCS-1.34

CAS No.: 24725-65-3

LCS-1.34 (LCS1.34)

Catalog No.: PC-62033Not For Human Use, Lab Use Only.

LCS-1.34 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.1-1.1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LCS-1.34 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.1-1.1 uM.
Superoxide dismutase 1 (SOD1) is the most likely target o, LCS-1.34 inhibits SOD1 in a dose-dependent manner with IC50 of 1.07 uM.
LCS-1.34 inhibits MAPK and PI3-kinase pathways, DNA synthesis and induces apoptosis.

Physicochemical Properties

M.Wt 309.955
Formula C10H4Cl4N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4,5-dichloro-2-(2,4-dichlorophenyl)pyridazin-3(2H)-one

References

1. Somwar R, et al. J Biomol Screen. 2009 Dec;14(10):1176-84.

2. Somwar R, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80.

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