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Chemical Structure : LDH-IN-1
CAS No.: 1964515-43-2
Catalog No.: PC-23017Not For Human Use, Lab Use Only.
LDH-IN-1 (LDH inhibitor 63) is a potent, selective and cell-active lactate dehydrogenase (LDH) inhibitor with IC50 of 32 nM/27 nM for LDHA/LDHB respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | Get quote |
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LDH-IN-1 (LDH inhibitor 63) is a potent, selective and cell-active lactate dehydrogenase (LDH) inhibitor with IC50 of 32 nM/27 nM for LDHA/LDHB respectively.
LDH inhibitor 63 shows negligible activity against both MDH and IDH1 (IC50>20 uM).
LDH inhibitor 63 exhibits IC50 of 0.85 uM in cell-based lactate production assay using the A673 human sarcoma and MiaPaCa-2 human pancreatic cancer.
LDH inhibitor 63 demonstrated cellular target engagement, slow in vitro off-rate and good microsomal stability and aqueous solubility.
| M.Wt | 570.68 | |
| Formula | C30H26N4O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(3-([1,1'-Biphenyl]-3-yl)-5-(cyclopropylmethyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid |
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1. Rai G, et al. J Med Chem. 2017 Nov 22;60(22):9184-9204.
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