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Chemical Structure : LDK1229
Catalog No.: PC-63019Not For Human Use, Lab Use Only.
LDK1229 is a novel potent, selective cannabinoid CB1 receptor inverse agonist with Ki of 220 nM.
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LDK1229 is a novel potent, selective cannabinoid CB1 receptor inverse agonist with Ki of 220 nM.
LDK1229 exhibits 3-fold relative selectivity for the CB1 over CB2, exhibits efficacy comparable with SR141716A in antagonizing the basal G protein coupling activity of CB1.
LDK1229 increases cell surface localization of CB1 and structurally distinct from the first-generation CB1 inverse agonists.
| M.Wt | 434.956 | |
| Formula | C24H29ClF2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mahmoud MM, et al. Mol Pharmacol. 2015 Feb;87(2):197-206.
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