LDN-27219 | TGase inhibitor | Probechem Biochemicals

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Chemical Structure : LDN-27219

CAS No.: 312946-37-5

LDN-27219 (LDN 27219, LDN 27219)

Catalog No.: PC-45039Not For Human Use, Lab Use Only.

LDN-27219 is a potent, reversible inhibitor of hTGase (Tissue transglutaminase) with IC50 of 0.8 uM.

Packing	Price	Stock
10 mg	$98	In stock
25 mg	$158	In stock
50 mg	$258	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LDN-27219 is a potent, reversible inhibitor of hTGase (Tissue transglutaminase) with IC50 of 0.8 uM.
LDN-27219 does not bind at the enzyme's active site but rather at the enzyme's GTP site, or a site that regulates binding of GTP.

Physicochemical Properties

M.Wt	408.4966
Formula	C20H16N4O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 4.3 mg/mL
Chemical Name/SMILES	Acetic acid, 2-[(3,4-dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-, hydrazide

References

1. Duval E, et al. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1885-9.

2. Case A, et al. Biochemistry. 2007 Jan 30;46(4):1106-15.

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LDN-27219 (LDN 27219, LDN 27219)

Biological Activity

Physicochemical Properties

References

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