LDT409

Chemical Structure : LDT409

Catalog No.: PC-22386Not For Human Use, Lab Use Only.

LDT409 is a small molecule, orally active partial agonist of pan PPARα/γ/δ with EC50 of 0.5 uM, 0.9 uM and 33 uM for huamn PPARα and PPARγ, respectively.

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Biological Activity

LDT409 is a small molecule, orally active partial agonist of pan PPARα/γ/δ with EC50 of 0.5 uM, 0.9 uM and 33 uM for huamn PPARα and PPARγ, respectively.
LDT409 activates PPARα target genes in primary hepatocytes in a gene-selective manner.
LDT409 differentially regulate the expression of PPARγ target genes and adipocyte differentiation in 3T3-L1 cells.
LDT409 demonstrates tissue-specific activation of PPARα and PPARγ in an in vivo zebrafish embryo model.
LDT409 reverses HFD-induced weight gain back to chow-fed control levels, improves glucose homeostasis and plasma lipids in HFD-fed mice.

Physicochemical Properties

M.Wt	390.61
Formula	C25H42O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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LDT409

Biological Activity

Physicochemical Properties

References

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