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Chemical Structure : LE-540
Catalog No.: PC-70292Not For Human Use, Lab Use Only.
LE-540 (LE540) is a potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements.
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LE-540 (LE540) is a potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements.
LE-540 inhibits ATRA-induced apoptosis in ZR-75-1 human breast cancer cells.
LE-540 strongly represses 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARβ and RARα.
| M.Wt | 488.631 | |
| Formula | C33H32N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li Y, et al. J Biol Chem. 1999 May 28;274(22):15360-6.
2. Kitaoka K, et al. Brain Res. 2011 Nov 14;1423:10-6.
3. Umemiya H, et al. J Med Chem. 1997 Dec 19;40(26):4222-34.
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