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LEI-102

Chemical Structure : LEI-102

CAS No.: 1228659-40-2

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LEI-102 (LEI 102)

Catalog No.: PC-20746Not For Human Use, Lab Use Only.

LEI-102 (LEI 102) is a potent, selective cannabinoid CB2 receptor agonist with binding pKi of 8.0, 1000-fold selectivity over CB1R.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LEI-102 (LEI 102) is a potent, selective cannabinoid CB2 receptor agonist with binding pKi of 8.0, 1000-fold selectivity over CB1R.
LEI-102 is more potent than the selective CB2R agonists APD371 and HU308.
LEI-102 activates CB2R as a partial agonist (Emax 76 ± 1%) with a pEC50 value of 6.9 in G protein activation assays.

Physicochemical Properties

M.Wt 454.55
Formula C25H31FN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-(5-fluoro-6-(((tetrahydro-2H-pyran-4-yl)amino)methyl)pyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione

References

1. Xiaoting Li, et al. Nat Commun. 2023 Mar 15;14(1):1447.

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