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LEI-945

Chemical Structure : LEI-945

CAS No.: 2582758-03-8

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LEI-945 (LEI 945)

Catalog No.: PC-20139Not For Human Use, Lab Use Only.

LEI-945 (LEI 945) is a first-in-class probe that enables profiling retinaldehyde dehydrogenases (ALDHs) in cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LEI-945 (LEI 945) is a first-in-class probe that enables profiling retinaldehyde dehydrogenases (ALDHs) in cancer cells.
    LEI-945 can be used for the activity-based protein profiling (ABPP) of retinaldehyde dehydrogenases, ALDH1A1, ALDH1A2 and ALDH1A3.
    LEI-945 enables the quantification of ALDH isozyme activities in a panel of cancer cell lines via both fluorescence and chemical proteomic approaches.

    Physicochemical Properties

    M.Wt 364.53
    Formula C25H32O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4E,6E,8E,10E)-5,9-dimethyl-11-(2,6,6-trimethyl-4-(prop-2-yn-1-yloxy)cyclohex-1-en-1-yl)undeca-1,4,6,8,10-pentaen-3-one

    References

    1. Koenders STA, et al. ACS Cent Sci. 2019 Dec 26;5(12):1965-1974.

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