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Chemical Structure : LF3
CAS No.: 664969-54-4
Catalog No.: PC-42398Not For Human Use, Lab Use Only.
A small-molecule antagonist of the β-catenin/TCF4 interaction with IC50 of 1.65 and 1.82 uM in AlphaScreen and ELISA assay, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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LF3 is a small-molecule antagonist of the β-catenin/TCF4 interaction with IC50 of 1.65 and 1.82 uM in AlphaScreen and ELISA assay, respectively.
LF3 potently and selectively inhibits activated Wnt/β-catenin signals in reporter cells (IC50=2.4-4 uM), does not cause cell death and interfere with the interaction of β-catenin with E-cadherin.
LF3 reduces tumor growth and induces differentiation in a mouse xenograft model of colon cancer.
| M.Wt | 416.56016 | |
| Formula | C20H24N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
|
| Chemical Name/SMILES |
1-Piperazinecarbothioamide, N-[4-(aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)- |
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1. Fang L, et al. Cancer Res. 2016 Feb 15;76(4):891-901.
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