Catalog No.: PC-23687Not For Human Use, Lab Use Only.
LG100268 (LG268) is a potent, selective, orally active retinoid X receptor (RXR) agonist with EC50 of 4 nM, 3 nM, and 4 nM for RXRα, RXRβ, and RXRγ, respectively.
LG100268 (LG268) is a potent, selective, orally active retinoid X receptor (RXR) agonist with EC50 of 4 nM, 3 nM, and 4 nM for RXRα, RXRβ, and RXRγ, respectively. LG100268 displays >1000-fold selectivity for RXR over RAR, and has Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXRα, RXRβ, and RXRγ, respectively. LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 shows anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.
