Chemical Structure : LG101506
CAS No.:
331248-11-4
LG101506
(LG 101506, LG1506)
Catalog No.: PC-20830Not For Human Use, Lab Use Only.
LG101506 (LG1506) is a potent, selective and orally active RXR modulator with Ki of 2.6 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LG101506 (LG1506) is a potent, selective and orally active RXR modulator with Ki of 2.6 nM.
LG101506 binds RXRalpha and activates RXR homo and heterodimers.
LG1506 is a potent insulin sensitizer that also enhances the insulin-sensitizing activities of rosiglitazone.
Administration of LG1506 reduces both body weight gain and food consumption and blocks the TZD-induced weight gain when coadministered with rosiglitazone.
LG1506 does not significantly suppress the thyroid hormone axis in rats, nor does it elevate triglycerides in Sprague Dawley rats.
LG1506 elevates high-density lipoprotein cholesterol in humanized apolipoprotein A-1-transgenic mice.
Physicochemical Properties
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M.Wt
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420.54
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Formula
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C25H34F2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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FC(F)COC1=C(C=C(C=C1/C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)C)C(C)(C)C
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References
1. Leibowitz MD, et al. Endocrinology. 2006 Feb;147(2):1044-53.
2. Gernert DL, et al. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3191-5.
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