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LGB-321

Chemical Structure : LGB-321

CAS No.: 1210416-93-5

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LGB-321 (LGB 321;LGB321)

Catalog No.: PC-70113Not For Human Use, Lab Use Only.

LGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively.
LGB-321 inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in PIM2-dependent MM cell lines.
LGB-321 shows activity in cell lines derived from diverse hematological lineages, including ALL, AML, NHL.
LGB-321 shows activity in the KG-1 AML xenograft model, and synergizes with cytarabine.

Physicochemical Properties

M.Wt 530.37
Formula C23H24Cl2F3N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide hydrochloride

References

1. Garcia PD, et al. Clin Cancer Res. 2014 Apr 1;20(7):1834-45.

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