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LI-2242

Chemical Structure : LI-2242

CAS No.: 2762762-17-2

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LI-2242 (LI 2242)

Catalog No.: PC-20859Not For Human Use, Lab Use Only.

LI-2242 is a potent pan-IP6K inhibitor with IC50 of with IC50 of 31, 42 and 8.1 nM for IP6K1, IP6K2 and IP6K3, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LI-2242 is a potent pan-IP6K inhibitor with IC50 of 31, 42 and 8.1 nM for IP6K1, IP6K2 and IP6K3, respectively.
LI-2242 (20 mg/kg/BW daily, i.p.) ameliorates obesity in DIO mice via a specific reduction in body fat, without substantially altering lean and fluid mass.
LI-2242 improves glycemic parameters in DIO mice.
LI-2242 treatment improves metabolic parameters in the adipose tissue of DIO mice.
LI-2242 treatment ameliorates steatosis, insulin resistance, and injury of the liver in DIO mice.
LI-2242 alters the metabolic parameters of adipocytes and hepatocytes in vitro.

Physicochemical Properties

M.Wt 405.28
Formula C20H18Cl2N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(C1=CC2=C(NC(C23CCN(CC4=CC=C(Cl)C=C4Cl)CC3)=O)C=C1)O

References

1. Sandip Mukherjee, et al. Biomolecules. 2023 May 20;13(5):868.

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