LIBX-A403

Chemical Structure : LIBX-A403

Catalog No.: PC-25149Not For Human Use, Lab Use Only.

LIBX-A403 is a potent, selective Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) inhibitor with IC50 of 49 nM and MST KD of 0.29 uM, with no activity against ACSL3.

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Biological Activity

LIBX-A403 is a potent, selective Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) inhibitor with IC50 of 49 nM and MST KD of 0.29 uM, with no activity against ACSL3.
LIBX-A403 protect cells from ferroptosis, prevents ferroptotic cell death in different cell models.
LIBX-A403 inhibits ferroptosis through an ACSL4-dependent mechanism.

Physicochemical Properties

M.Wt	363.37
Formula	C21H17NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (2E)-3-(2-benzoyl-3-acetamido-1-benzofuran-5-yl)prop-2-enoate

References

1. Charnelle E, et al. J Med Chem. 2025 Jul 19. doi: 10.1021/acs.jmedchem.5c00739.

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LIBX-A403

Biological Activity

Physicochemical Properties

References

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