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LIMK-IN-14

Chemical Structure : LIMK-IN-14

CAS No.: 1116570-97-8

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LIMK-IN-14

Catalog No.: PC-70098Not For Human Use, Lab Use Only.

LIMK-IN-14 is a potent, selective LIMK inhibitor with IC50 of 0.9 nM and 0.5 nM and 1.2 nM for LIMK1 and LIMK2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LIMK-IN-14 is a potent, selective LIMK inhibitor with IC50 of 0.9 nM and 0.5 nM and 1.2 nM for LIMK1 and LIMK2, respectively.
    LIMK-IN-14 displays >100-fold selectivity for LIMK2 against ROCK1 and >900-fold selectivity against ROCK2.
    LIMK-IN-14 reduces intraocular pressure to baseline levels in a steroid induced mouse model of ocular hypertension (topical dosing).

    Physicochemical Properties

    M.Wt 437.504
    Formula C22H27N7O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamido)phenyl dimethylcarbamate

    References

    1. Harrison BA, et al. J Med Chem. 2009 Nov 12;52(21):6515-8.

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