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LIMK-IN-22j

Chemical Structure : LIMK-IN-22j

CAS No.: 1116571-01-7

LIMK-IN-22j (LIMK-IN-1)

Catalog No.: PC-70097Not For Human Use, Lab Use Only.

LIMK-IN-22j (LIMK-IN-1) is a potent, selective LIMK inhibitor with IC50 of 3.2 nM and 1.2 nM for LIMK1 and LIMK2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LIMK-IN-22j (LIMK-IN-1) is a potent, selective LIMK inhibitor with IC50 of 3.2 nM and 1.2 nM for LIMK1 and LIMK2, respectively.
LIMK-IN-22j (LIMK-IN-1) displays >100-fold selectivity for LIMK2 against ROCK1 and >900-fold selectivity against ROCK2.
LIMK-IN-22j (LIMK-IN-1) reduces intraocular pressure to baseline levels in a steroid induced mouse model of ocular hypertension (topical dosing).

Physicochemical Properties

M.Wt 453.348
Formula C20H21BrN8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S,Z)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide

References

1. Harrison BA, et al. J Med Chem. 2009 Nov 12;52(21):6515-8.

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