LIMK1 and 2 dual inhibitor 1|CAS:2215049-71-9 Probechem Biochemicals

Chemical Structure : LIMK1 and 2 dual inhibitor 1

LIMK1 and 2 dual inhibitor 1 (LIMK1/2-IN-1)

Catalog No.: PC-35249Not For Human Use, Lab Use Only.

LIMK1 and 2 dual inhibitor 1 (LIMK1/2-IN-1) is a potent, selective LIMK1/2 inhibitor with IC50 of <10 nM for both, 15-fold selectivity over B-Raf (IC50=10-100 nM).

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Biological Activity

LIMK1 and 2 dual inhibitor 1 (LIMK1/2-IN-1) is a potent, selective LIMK1/2 inhibitor with IC50 of <10 nM for both, 15-fold selectivity over B-Raf (IC50=10-100 nM).
inhibits p-c-ofilin at Ser3 site, suppresses cell proliferation of MV-411 cell of with IC50 of 1-5 uM.

Physicochemical Properties

M.Wt	610.63
Formula	C28H21F3N6O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)-5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylacetamide

References

1. US Patent WO 2018055097.

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LIMK1 and 2 dual inhibitor 1 (LIMK1/2-IN-1)

Biological Activity

Physicochemical Properties

References

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