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LIN28 inhibitor LI71

Chemical Structure : LIN28 inhibitor LI71

CAS No.: 1357248-83-9

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LIN28 inhibitor LI71 (LI71)

Catalog No.: PC-35201Not For Human Use, Lab Use Only.

LIN28 inhibitor LI71 is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 7 uM, binds the cold shock domain to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LIN28 inhibitor LI71 is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 7 uM, binds the cold shock domain to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells.

Physicochemical Properties

M.Wt 335.403
Formula C21H21NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid

References

1. Wang L, et al. Cell Rep. 2018 Jun 5;23(10):3091-3101.

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