LLK203 | USP2/USP8 inhibitor | Probechem Biochemicals

Chemical Structure : LLK203

LLK203 (LLK 203)

Catalog No.: PC-21919Not For Human Use, Lab Use Only.

LLK203 is a potent, dual-targeting USP2/USP8 inhibitor with IC50 of 0.89/0.52 uM, potently inhibits cell proliferation of MCF-7 breast cancer cells with IC50 of 3.4 uM.

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Biological Activity

LLK203 is a potent, dual-targeting USP2/USP8 inhibitor with IC50 of 0.89/0.52 uM, potently inhibits cell proliferation of MCF-7 breast cancer cells with IC50 of 3.4 uM.
LLK203 demonstrates strong degradation activity towards MDM2 and Cyclin D1, also induces ERα degradation and apoptosis of MCF-7 cells.
LLK203 (20 mg/kg, i.p.) exhibits tumor growth inhibitory efficacy of LLK203 in 4T1 tumor-bearing mice.

Physicochemical Properties

M.Wt	561.69
Formula	C28H23N3O4S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-methoxy-2-((4-(5-methylthiophen-2-yl)phenyl)sulfonamido)-N-(4-phenylthiazol-2-yl)benzamide

References

1. Tian Y, et al. Eur J Med Chem. 2024 Feb 24;268:116275.

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LLK203 (LLK 203)

Biological Activity

Physicochemical Properties

References

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