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Chemical Structure : LLK203
Catalog No.: PC-21919Not For Human Use, Lab Use Only.
LLK203 is a potent, dual-targeting USP2/USP8 inhibitor with IC50 of 0.89/0.52 uM, potently inhibits cell proliferation of MCF-7 breast cancer cells with IC50 of 3.4 uM.
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LLK203 is a potent, dual-targeting USP2/USP8 inhibitor with IC50 of 0.89/0.52 uM, potently inhibits cell proliferation of MCF-7 breast cancer cells with IC50 of 3.4 uM.
LLK203 demonstrates strong degradation activity towards MDM2 and Cyclin D1, also induces ERα degradation and apoptosis of MCF-7 cells.
LLK203 (20 mg/kg, i.p.) exhibits tumor growth inhibitory efficacy of LLK203 in 4T1 tumor-bearing mice.
| M.Wt | 561.69 | |
| Formula | C28H23N3O4S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tian Y, et al. Eur J Med Chem. 2024 Feb 24;268:116275.
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