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LLY-283

Chemical Structure : LLY-283

CAS No.: 2040291-27-6

LLY-283 (LLY283)

Catalog No.: PC-63461Not For Human Use, Lab Use Only.

LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM.
LLY-283 displays excellent against other arginine methyltransferases including the closely related PRMT7 and the type II PRMTs such as PRMT4 and 6.
LLY-283 decreases SmBB’-Rme2s levels in MCF7 cells with IC50 of 25 nM, also inhibits the PRMT5 mediated regulation of the splicing of MDM4.
LLY-283 inhibits proliferation of A375 cells with IC50 of 45.6 nM.
LLY-283 inhibits Tumor growth in mouse xenograft (A375, 20 mg/kg; QD).

Physicochemical Properties

M.Wt 342.36
Formula C17H18N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol

References

1. Zahid Q. Bonday, et al. ACS Med. Chem. Lett. 2018. DOI: 10.1021/acsmedchemlett.8b00014.

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