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LMD-A

Chemical Structure : LMD-A

CAS No.: 850330-77-7

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LMD-A (CCR8 antagonist LMD-A)

Catalog No.: PC-60855Not For Human Use, Lab Use Only.

LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM.
    LMD-A inhibits 10 nM CCL1-induced activation of CCR8 with EC50 of 12 nM.
    LMD-A inhibits 4DE4 cells cell migration induced by 3 nM CCL1 with EC50 of 0.58 nM.

    Physicochemical Properties

    M.Wt 508.637
    Formula C27H32N4O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(N-((3R,4R)-1-(L-alanyl)-3-methylpiperidin-4-yl)sulfamoyl)naphthalen-1-yl)-2-methylbenzamide

    References

    1. Rummel PC, et al. Br J Pharmacol. 2012 Nov;167(6):1206-17.

    2. Barington L, et al. J Biol Chem. 2016 Jul 29;291(31):16208-20.

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