Chemical Structure : LMT2368
CAS No.:
2961608-06-8
LMT2368
(LMT-2368)
Catalog No.: PC-25673Not For Human Use, Lab Use Only.
LMT2368 is a small molecule urea-based NLRP3 inhibitor, binds to NLRP3 NACHT domain with KD of 27.4 uM, dose-dependently suppresses IL-1β secretion (IC50=0.8 μM in J774A.1 cells) and caspase-1 activation without affecting NF-κB signaling.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LMT2368 is a small molecule urea-based NLRP3 inhibitor, binds to NLRP3 NACHT domain with KD of 27.4 uM, dose-dependently suppresses IL-1β secretion (IC50=0.8 μM in J774A.1 cells) and caspase-1 activation without affecting NF-κB signaling.
LMT2368 inhibited ASC oligomerization and pyroptosis while maintaining excellent safety margins (CC50 > 50 μM).
LMT2368 (10 mg/kg) reduced bronchoalveolar lavage fluid immune cell infiltration by 68% in murine model of LPS-induced acute lung injury, suppressed pro-inflammatory cytokine release (IL-1β/IL-6/TNF-α), and preserved lung histoarchitecture.
LMT2368 showed selectivity for NLRP3 inhibition without affecting TNF-α/IL-6 production during TLR4 priming in monocytic cell lines.
Physicochemical Properties
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M.Wt
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332.68
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Formula
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C14H9ClF4N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(4-Chlorophenyl)-3-(3-fluoro-5-(trifluoromethyl)phenyl)urea
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References
1. Nguyen TU, et al. Pharmaceutics. 2025 Sep 23;17(10):1241.
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