LN5972 | ACKR3 agonist | Probechem Biochemicals

Chemical Structure : LN5972

LN5972 (LN-5972)

Catalog No.: PC-22931Not For Human Use, Lab Use Only.

LN5972 (LN-5972) is a potent, selective and first-in-class agonist of the atypical chemokine receptor 3 (ACKR3, CXCR7) with β-arrestin EC50 of 3.4 uM.

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Biological Activity

LN5972 (LN-5972) is a potent, selective and first-in-class agonist of the atypical chemokine receptor 3 (ACKR3, CXCR7) with β-arrestin EC50 of 3.4 uM.
LN5972 effectively reduced P-selectin expression by up to 97% in a platelet degranulation assay, showed potential for the treatment of platelet-mediated thrombosis.

Physicochemical Properties

M.Wt	422.55
Formula	C19H30N6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-Butyl 4-(3-((7-Ethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino)propyl)ppiperazine-1-carboxylate

References

1. Alp Bayrak, et al. J Med Chem. 2022 Oct 13;65(19):13365-13384.

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LN5972 (LN-5972)

Biological Activity

Physicochemical Properties

References

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