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Chemical Structure : LN5P45
CAS No.: 2307750-78-1
Catalog No.: PC-21098Not For Human Use, Lab Use Only.
LN5P45 is a selective, covalent, irreversible inhibitor of ubiquitin thioesterase OTUB2 with IC50 of 2.3 uM, strongly induces monoubiquitination of OTUB2 on Lys31.
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|---|---|---|---|
| 10 mg | $458 | In stock | |
| 25 mg | $748 | In stock | |
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LN5P45 is a selective, covalent, irreversible inhibitor of ubiquitin thioesterase OTUB2 with IC50 of 2.3 uM, strongly induces monoubiquitination of OTUB2 on Lys31.
LN5P45 is about 20-fold more potent toward OTUB2 over OTUD3 (IC50=56 uM).
LN5P45 also shows no activity against the closest family members OTUB1, OTUD1, OTUD2, OTUD3, OTUD6B, and Cezanne, and DUBs UCHL1 and USP16 (IC50>100 uM).
LN5P45 (10 uM) displays clear inhibition of GFP-OTUB2 in HEK293T cells, LN5P45 engages endogenous OTUB2 and is selective for OTUB2 over other ubiquitin machinery components.
| M.Wt | 266.73 | |
| Formula | C13H15ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1S,2S)-N'-(2-chloroacetyl)-2-(m-tolyl)cyclopropane-1-carbohydrazide |
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1. Jin Gan, et al. ACS Chem Biol. 2023 Aug 29.
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