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LN6023

Chemical Structure : LN6023

CAS No.: 3035427-42-7

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LN6023 (LN-6023)

Catalog No.: PC-49368Not For Human Use, Lab Use Only.

LN6023 (LN-6023) is a potent, selective and first-in-class agonist of the atypical chemokine receptor 3 (ACKR3, CXCR7) with β-arrestin EC50 of 3.5 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LN6023 (LN-6023) is a potent, selective and first-in-class agonist of the atypical chemokine receptor 3 (ACKR3, CXCR7) with β-arrestin EC50 of 3.5 uM.
    LN6023 effectively reduced P-selectin expression by up to 97% in a platelet degranulation assay, showed potential for the treatment of platelet-mediated thrombosis.

    Physicochemical Properties

    M.Wt 420.576
    Formula C20H32N6O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(tert-butyl)-1-(3-((7-ethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino)propyl)piperidine-4-carboxamide

    References

    1. Alp Bayrak, et al. J Med Chem. 2022 Oct 13;65(19):13365-13384.

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